Manfred Philipp

Ph.D. in Biochemistry, Northwestern University; B.S. in Chemistry, Michigan Technological University; Postdoctorals at the Johns Hopkins University and the University of Freiburg.

E-mail: philipp@lehman.cuny.edu- Telephone:+1-718-960-8648 - FAX: +1-419-818-7246

Current Duties
 
• Department Chair and Professor of Chemistry, Lehman College of the City University of New York
• Deputy Executive Officer, Biochemistry Ph.D. Program, Graduate School & University Center of CUNY
• Professor of Biochemistry, Biology, & Chemistry, Graduate School & University Center/CUNY
• Member:
• Faculty Advisory Council, Research Foundation of CUNY
• Board of Directors of the CUNY Research Foundation
• Executive Committee, the University Faculty Senate of CUNY
• Lehman College Senate
• Alternate Faculty Member, CUNY Board of Trustees Committees on Faculty, Staff, & Administration and on Student Affairs
• Vice-Chair, Lehman College Chapter of the Professional Staff Congress of CUNY


Past Duties:
 

• President, MBRS/MARC Program Directors Organization
• Chair, Faculty Advisory Council, Research Foundation of CUNY
• Founding Webmaster, Professional Staff Congress of CUNY
• Program Director for Minority Biomedical Research Support and Minority Access to Research Careers, Lehman College/CUNY
• Program Director for Bridges to the Baccalaureate, jointly with Prof. John Davis of Bronx Community College/CUNY
• Faculty Coordinator, Lehman College's European Union-United States Cooperation in Higher Education
• Chair, Biochemistry & Molecular Biology Review Panel, PSC-CUNY Program, Research Foundation of CUNY
• Visiting Professor, University of Ulm
• President, Lehman College Chapter of Sigma Xi, the Scientific Research Society

People in this research group:

• CUNY Biochemistry Ph.D. Program:  Raji Thamarathu

Courses taught at the City University of New York:
 

Undergraduate: Lehman College	Graduate: Lehman College
CHE 114: Essentials of General Chemistry-Lecture CHE 115: Essentials of General Chemistry-Laboratory CHE 120: Essentials of Organic Chemistry  Lecture CHE 121: Essentials of Organic Chemistry Laboratory CHE 233: Organic Chemistry Laboratory I. CHE 235: Organic Chemistry Laboratory II CHE 446: Biochemistry II CHE 447: Biochemistry Laboratory.	CHE 560:  Topics in Chemistry: Chemoinformatics Graduate: CUNY Graduate Center Biochem. U710,  Advanced Biochemistry Biochem. U711,  Research Techniques in Biochemistry Biochemistry U750 - Bioorganic Chemistry Biochemistry U840 Enzymology Biochemistry 88900 - Bioinformatics

Grant abstracts:

National Institutes of Health: 1R15DK37885-01, S2S03RR03421-09, 2S03RR03421-10, 2S06GM08225-11, 3S06GM08225-11S1, 5S06GM08225-12, 3S06GM08225-12S1, 5S06GM08225-13, 3S06GM08225-13S1, 5S06GM08225-14, 3T34GM08182-09S1, 2T34GM08182-10, 5T34GM08182-11,  and NIH 2R25GM50071-02  (Co-PI: Prof. John Davis of Bronx Community College).

National Science Foundation: NSF9414002 (Co-PI: Prof. Barbara Meurer-Grimes of the Lehman College Department of Biological Sciences.) and NSF8952041.

Patents:

• "Inhibitors of Trypsin-Like Enzymes," by Göran Claeson & Manfred Philipp, U.S. Patent No. 6,114,308,  issued September 5, 2000.Assignee: Trigen, London.
• "Inhibitors of Trypsin-Like Enzymes," by Göran Claeson, Manfred Philipp, & Rainer Metternich, U.S. Patent No. 5,856,306,  issued January 5, 1999. and, U.S. Patent No.5,574,014, issued November 12, 1996. Assignee: The Thrombosis Research Trust, London.
• "Method for Visualizing the Base Sequence of Nucleic Acid Polymers," Stuart Lindsay & Manfred Philipp, U.S. Patent No.5,106,729, issued April 21, 1992. Assignee: Arizona State University, Tempe.
• "Method for Visualizing the Base Sequence of Nucleic Acid Polymers," Stuart Lindsay & Manfred Philipp, European Patent No. EP410618A3, issued March 11, 1992. and European Patent No.EP410618A2, issued Janury 30, 1991.Assignee: Arizona State University, Tempe.
• "Method of Purifying Enzymes using Boronic Acids Covalently Bonded to an Insoluble Support," Manfred Philipp, Myron L. Bender, & Pablo V. Valenzuela, U.S. Patent No.3,912,595, issued October 14, 1975. Assignee: The US Department of Health, Education, & Welfare.

Selected Publications and Abstracts (Medline):

• Inhibition of serine proteases by arylboronic acids. Philipp M, Bender ML Proc Natl Acad Sci U S A 68,  478-80 (1971) Medline
• Is binding the rate-limiting step in acylation of a-chymotrypsin by specific substrates?  Philipp M, Bender ML Nature New Biology,  241: 44 (1973) Medline
• Subtilisin catalysis of nonspecific anilide hydrolyses. Bender ML, Philipp M, J Am Chem Soc 1973 95:1665-6 Medline
• Subtilisin-catalyzed hydrolysis of peptide methyl esters.Philipp M, Bender ML FEBS Lett. 42 :282-4 (1974) Medline
• Binding rates, O--S substitution effects, and the pH dependence of chymotrypsin reactions.Hirohara H, Philipp M, Bender ML, Biochemistry 16:1573-80 (1977) Medline
• Spontaneous phosphorylation of nucleosides in formamide--ammonium phosphate mixtures. Philipp M, Naturwissenschaften 64:273 (1977) Medline
• Rabbit b-globin mRNA sequences bounding a noncoding insert are self-complementary. Philipp M, Ballinger D Naturwissenschaften 65:388-9 (1978) Medline
• Comparison of the kinetic specificity of subtilisin and thiolsubtilisin toward n-alkyl p-nitrophenyl esters. Philipp M, Tsai IH, Bender ML, Biochemistry 18:3769-73 (1979) Medline
• Preparation of immobilized phosphodiesterase from calf spleen and its use in oligonucleotide analysis.Seliger H, Teufel EH, Philipp M Biotechnol Bioeng 22: 55-64 (1980) Medline
• Non-stepwise methods in the preparation of building blocks for polynucleotide synthesis. Seliger H; Haas B; Holupirek M; Knable T; Todling G; Philipp M Nucleic Acids Symp Ser;(7):191-202 (1980) Medline
• Inhibition of subtilisin by substituted arylboronic acids.Philipp M; Maripuri S, FEBS Lett 133 :36-8 (1981) Medline
• Kinetics of subtilisin and thiolsubtilisin.Philipp M; Bender ML Mol Cell Biochem ;51::5-32 (1983) Medline
• Can the scanning tunneling microscope sequence DNA?   Lindsay SM; Philipp M & Wurtzel, E., Genet Anal Tech Appl 8: 8-13 (1991) Medline
• Irreversible inhibition of a monoclonal antibody by a nitrophenyl ester. Rao G; Philipp M  J Protein Chem  10:117-22 (1991) Medline
• "pH-Dependent Kinetics of Tight-Binding Thrombin Inhibitors," by T. DeSoyza, L.-H. Niu, M. Philipp, G. Claeson, R. Metternich, Advances in Experimental Biology and Medicine, Volume on The Design of Synthetic Inhibitors of Thrombin, G. Claeson et. al. eds., Plenum, 1993, pages 67-77. Medline
• "Z-D-Phe-Pro-methoxypropyl-boroGlycine - a Novel Inhibitor of Thrombin with High Selectivity Containing a Neutral Side Chain at the P₁ Position," G. Claeson, M. Philipp, E. Agner, M.F. Skully, V.V. Kakkar, T. DeSoyza, & L.-H. Niu, Biochemical Journal, 290, 309-312 (1993). Medline
• "Biomimetric Catalysis: Boronic Acids Accelerate the Formation of Salicylaldehyde Imines", L.-H. Niu, B. Frias, S. Sharma, & M. Philipp, FASEB Journal, 7(7)A 1177-727 (1993).
• "pH-Dependencies for Substrates and Inhibitors of Thrombin," L.-H. Niu, T. DeSoyza, G. Claeson, E. Agner, & M. Philipp, Thrombosis and Haemostasis, 69(6) 1316 (1993).
• "Slow Inhibitors of Thrombin," by L.-H. Niu, T. DeSoyza, G. Claeson, R. Metternich, & M. Philipp, FASEB Journal,7(7), A1183-761 (1993).
• "Computer Assisted Instruction in the Biochemistry Curriculum," by M. Philipp, R. L. Baumgarten, J. Dayan, C. Dougherty, & J. Richards, FASEB Journal,7(7) A1130-449, (1993).
• "Boronic Acids as Enzyme Models: Catalysis of Oxime Formation," by Ling-Hao Niu, Bernarda Frias, Subodh Sharma, & M. Philipp, Special Publication: Royal Society of Chemistry, 143, 185-188 (1994).
• "Foreign Student Exchanges with German Universities," Letter to Science; 273 (5278):1029; August 23, 1996.
• How Does the NIH Support Undergraduate Research by Minority Students, Quarterly of the Council of Undergraduate Research, December 1999
• "Call a Halt to Strong-Arm Tactics Over GM Crops," Letter to Nature, 400,  499 (1999) Medline